Christer Betsholtz and Alan D . Attie Dawson , Mary E . Rabaglia , Angie T . Oler , Donald S . Stapleton , Guillem Genové , John A . Summer M . Raines , Oliver C . Richards ,
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چکیده
endocrine and metabolic systems on any level of organization. It is published 12 times a year (monthly) by the publishes results of original studies about
منابع مشابه
1 Loss of PDGF - B activity increases hepatic vascular 2 permeability and enhances insulin sensitivity 3 4 Running title : PDGF - B deficiency enhances insulin sensitivity
Running title: PDGF-B deficiency enhances insulin sensitivity 5 6 Summer M. Raines, Oliver C. Richards, Lindsay R. Schneider, Kathryn L. Schueler, Mary 7 E. Rabaglia, Angie T. Oler, Donald S. Stapleton, Guillem Genové, John A. Dawson, Christer 8 Betsholtz, and Alan D. Attie 9 10 11 Department of Biochemistry; University of Wisconsin-Madison; Madison, WI 53706 12 Graduate Program in Cellular and...
متن کاملLoss of PDGF-B activity increases hepatic vascular permeability and enhances insulin sensitivity.
Hepatic vasculature is not thought to pose a permeability barrier for diffusion of macromolecules from the bloodstream to hepatocytes. In contrast, in extrahepatic tissues, the microvasculature is critically important for insulin action, because transport of insulin across the endothelial cell layer is rate limiting for insulin-stimulated glucose disposal. However, very little is known concerni...
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Access the most recent version at doi: published online Mar 17, 2008; Genome Res. Alan D Attie Robert Kleinhanz, Scott Turner, Marc K Hellerstein, Eric E Schadt, Brian S Yandell, Christina Kendziorski and Stapleton, Carmen Argmann, Kathryn L Schueler, Seve Edwards, H Adam Steinberg, Elias Chaibub Neto, Mark P Keller, YounJeong Choi, Ping Wang, Dawn Belt Davis, Mary E Rabaglia, Angie T Oler, Don...
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We previously positionally cloned Sorcs1 as a diabetes quantitative trait locus. Sorcs1 belongs to the Vacuolar protein sorting-10 (Vps10) gene family. In yeast, Vps10 transports enzymes from the trans-Golgi network (TGN) to the vacuole. Whole-body Sorcs1 KO mice, when made obese with the leptin(ob) mutation (ob/ob), developed diabetes. β Cells from these mice had a severe deficiency of secreto...
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Departments of Biochemistry (J.A.L., P.W.R., D.S.S., M.E.R., J.I.S., K.L.S., J.E.K., D.B.D., M.P.K., A.D.A.), Statistics (J.A.D., B.S.Y.), and Medicine, Section of Endocrinology (D.B.D.), University of Wisconsin, Madison, Wisconsin 53706; Department of Molecular and Integrative Physiology (L.C.S.), University of Michigan, Ann Arbor, Michigan 48109; Department of Pharmacology and Experimental Th...
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تاریخ انتشار 2011